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Monocykliczne poliprenylowane acylofloroglucynole z szyszek chmielu zwyczajnego (Humulus lupulus) – perspektywy stosowania w żywieniu zwierząt

s. 58-66

Sylwia Stypuła-Trębas, Lidia Radko, Andrzej Posyniak

Zakład Farmakologii i Toksykologii, Państwowy Instytut Weterynaryjny-Państwowy Instytut Badawczy

Streszczenie. Obserwowana w ostatnich latach rosnąca antybiotykooporność spowodowała zainteresowanie przeciwbakteryjnymi substancjami pochodzenia roślinnego. Właściwości prozdrowotne i konserwacyjne szyszek chmielu są znane i wykorzystywane od wielu wieków. Do najbardziej bioaktywnych substancji obecnych w chmielu należą związki prenylowane, w tym poliprenylowane acylofloroglucynole, znane jako a i b- kwasy chmielowe. Ponieważ wykazują działanie przeciwbakteryjne, zwróciły uwagę jako potencjalne dodatki do pasz dla drobiu i przeżuwaczy. Celem pracy jest przegląd piśmiennictwa dotyczącego wielokierunkowej aktywności kwasów chmielowych oraz możliwości ich stosowania w roli dodatków paszowych w żywieniu zwierząt.

Słowa kluczowe: Humulus lupulus, kwasy chmielowe, lupulony, humulony, monocykliczne poliprenylowane acylofloroglucynole, aktywno biologiczna, fito-jonofory, przeciwbakteryjne promotory wzrostu, dodatki do pasz

Monocyclic polyprenylated acylphloroglucinpls from cones of hops (Humulus lupulus)  – perspectives of application in animal nutrition

Sylwia Stypuła-Trębas, Lidia Radko, Andrzej Posyniak

Department of Pharmacology and Toxicology, National Veterinary Research Institute

Summary. Increasing antibiotic resistance observed in recent years caused interest in plant-derived antimicrobial agents.   Health and preservative properties of hop cones are recognized and used from centuries. Among the most bioactive substances present in hops are prenylated compounds, including polyprenylated acylfloroglucinols, known as a- and b- acids. Because they show antibacterial properties, they are considered as potential additives for poultry and ruminants diets. The aim of the work is to review the literature concerning the multidirectional activity of hop acids and their applicability as feed additives in animal nutrition.

Keywords: Humulus lupulus, hop acids, lupulones, humulones, monocyclic polyprenylated acylphloroglucinols, biological activity, phyto-ionophores, antimicrobial growth promoter, feed additives

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